Area 51 » Science

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Neuroscience

Proposed Q&A site for methods questions on histology, electrophysiology, and molecular biology; to potentially provide a wealth of unpublished negative findings or failed attempts that other neuroscientists would benefit from without having to endure the frustration.
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<comments removed> If you have any questions or comments for this proposal, please use 'create new discussion' below. Thanks. – Robert Cartaino♦ Jul 26 '12 at 19:34

13 Example Questions

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up vote 10 down vote
What is the advantage of using tetrodes for neurophysiological recording over a microelectrode array or a single electrode?
added by John Jul 7 '12 at 21:13
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up vote 10 down vote
In training mice or rats in an operant task what sensory cue elicits an optimal learning curve?
added by John Jul 7 '12 at 21:43
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This question needs to be asked more carefully, but even in a very face-value form it has generated interesting discussion on CogSci.SE where it (like all of this proposal) is completely on-topic. – Artem Kaznatcheev Aug 23 '12 at 19:21
up vote 6 down vote
What are some artificial neural network architectures with biologically plausible accounts of neurogenesis?
added by Artem Kaznatcheev Jul 22 '12 at 9:53
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This question is off topic for this site. It is not technique focused. This question would be more appropriate at Cognitive Sciences. – John Jul 26 '12 at 2:59
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@John if computational modeling is off-topic as not technique focused, does that mean this site is only for experimental neuroscience techniques? If so, you should rename the proposal accordingly instead of the misleadingly broad Neuroscience title. – Artem Kaznatcheev Aug 9 '12 at 4:39
up vote 6 down vote
Are there imaging techniques that track specific neurotransmitters?
added by Artem Kaznatcheev Jul 22 '12 at 9:54
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Immunocytochemistry for transmitters or related transporters and synthetic enzymes is a common way of doing this. A more direct way of observing neurotransmitters is formaldehyde-induced fluorescence. – Anonymous Aug 2 '12 at 13:31
Excellent suggestion. Artem, it would help focus answers if you narrowed your question to a particular neurotransmitter, and perhaps indicate context of imaging (i.e. in vivo or in vitro). – John Aug 3 '12 at 4:29
Thanks @John, even the broad version of this question has generated interesting answers on CogSci.SE. – Artem Kaznatcheev Aug 9 '12 at 4:26
It is unclear what is meant by tracking here. Do you mean tracking the movement of a particular neurotransmitters in live tissue or just staining of a particular molecule? – Anonymous Mar 23 at 3:17
up vote 5 down vote
What is the best retrograde neural tracing compound (e.g. DiI, BDA, Cholera Toxin B), and sufficient time necessary for transmission?
added by John Jul 8 '12 at 19:00
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up vote 4 down vote
What are the advantages and disadvantages of using fluroscent vs. chromogenic detection of antigens using immunohistochemistry? Troubleshooting tips?
added by Jenn Jul 9 '12 at 0:15
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up vote 1 down vote
In motor movement disorders (e.g. Parkinsonian tremor) what r da problems/drawbacks with Reaction and Movement Time analysis for PD diagnosing?
added by Sal Jr Jul 15 '12 at 11:07
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up vote 1 down vote
What computational models can predict neural behavior over the span of days?
added by mac389 Aug 23 '12 at 2:09
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up vote 1 down vote
How are electroencephalographic (EEG) signals generated?
added by btel Oct 25 '12 at 13:03
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up vote 0 down vote
Using the GFAP antibody (AB5541) from Millipore to look at response to injury after lesion in the hippocampus I get strange labeling? Why? See image.
added by John Jul 9 '12 at 23:41
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up vote 0 down vote
Why does neuroplasticity decrease in adults?
added by Artem Kaznatcheev Jul 22 '12 at 9:53
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This question is off topic for this site. It is not technique focused. This question would be more appropriate at Cognitive Sciences. – John Jul 26 '12 at 2:57
It is more neuroscientific than cognitive in nature, so not entirely clear to me that it belongs in Cognitive Sciences. – Anonymous Mar 23 at 3:18
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@Anonymous that is the common misconception about Cognitive Sciences... it is not restricted to CogSci, it is just a bad name and all of neuroscience is on-topic there. The popular neuro tags are: neurobiology and theoretical-neuroscience – Artem Kaznatcheev Mar 23 at 3:54
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In fact, the question has been asked and answered on CogSci.SE – Artem Kaznatcheev Mar 23 at 3:55
up vote 0 down vote
How are newly created neurons recruited into existing networks?
added by Artem Kaznatcheev Jul 22 '12 at 9:53
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This question is off topic for this site. It is not technique focused. This question would be more appropriate at Cognitive Sciences. – John Jul 26 '12 at 2:58
up vote 0 down vote
What neurobiological changes are associated with the end of the critical period in children?
added by Artem Kaznatcheev Jul 22 '12 at 9:54
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This question is off topic for this site. It is not technique focused. This question would be more appropriate at Cognitive Sciences. – John Jul 26 '12 at 2:58

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